Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity

doi:10.1016/j.ijbiomac.2016.06.006

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	Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity
	Li, Q; Tan, WQ; Zhang, CL; Gu, GD; Guo, ZY; Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China. Email:[email protected]
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
	2016-10-01
卷号	91 页码:623-629
关键词	Chitosan Derivatives Antifungal Activity 1 Halogens 2 Electron-withdrawing Capacity 3-triazole
DOI	10.1016/j.ijbiomac.2016.06.006
产权排序	[Li, Qing; Tan, Wenqiang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China; [Tan, Wenqiang] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; [Zhang, Caili] Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
作者部门	海岸带生物学与生物资源利用所重点实验室
英文摘要	Chitosan is an abundant and renewable polysaccharide, which exhibits attractive bioactivities and natural properties. Improvement such as chemical modification of chitosan is often performed prior to further utilization. Three novel water soluble chitosan derivatives containing 1,2,3- triazole with or without halogen was designed and synthesized. Their antifungal activity against three kinds of phytopathogens was estimated by hyphal measurement in vitro. The inhibitory property and water solubility of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. It is hypothesized that thiazolyl groups enable the synthesized chitosan to possess obviously better antifungal activity. Moreover, CTCTS and BTCTS, which have halogens at the periphery of polymers, inhibited the growth of tested phytopathogens more effectively with inhibitory indices of 81-93% at 1.0 mg/mL. The halogens could have a synergistic effect with triazole as they exhibited antifungal activity and electron-withdrawing capacity, which improve the antifungal activity of chitosan derivatives. (C) 2016 Elsevier B.V. All rights reserved.
文章类型	Article
资助机构	National Natural Science Foundation of China(41576156) ; Shandong Province Science and Technology Development Plan(2015GSF121045) ; Yantai Science and Technology Development Plan(2015ZH078) ; Technology Research Funds Projects of Ocean(2015418022-3)
收录类别	SCI
语种	英语
关键词[WOS]	CLICK CHEMISTRY ; ANTIBACTERIAL ACTIVITY ; ANTITUMOR-ACTIVITY ; MAILLARD REACTION ; MOLECULAR-WEIGHT ; 1,2,4-TRIAZOLES ; INHIBITORS ; 1,2,3-TRIAZOLES ; ANTIOXIDANT ; CELLULASE
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:000382339200072
引用统计	被引频次：55[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/17195
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China. Email:[email protected]
推荐引用方式 GB/T 7714	Li, Q,Tan, WQ,Zhang, CL,et al. Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2016,91:623-629.
APA	Li, Q,Tan, WQ,Zhang, CL,Gu, GD,Guo, ZY,&Guo, ZY .(2016).Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,91,623-629.
MLA	Li, Q,et al."Synthesis of water soluble chitosan derivatives with halogeno-1,2,3-triazole and their antifungal activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 91(2016):623-629.

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