Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189

doi:10.1021/acs.jnatprod.6b00403

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	Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189
	Gao, SS; Li, XM; Williams, K; Proksch, P; Ji, NY; Wang, BG; Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao 266071, Peoples R China.; Proksch, P (reprint author), Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany.; Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China. Email:[email protected]; [email protected]; [email protected]
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
	2016-08-01
卷号	79 期号:8 页码:2066-2074
DOI	10.1021/acs.jnatprod.6b00403
产权排序	[Gao, Shu-Shan; Li, Xiao-Ming; Wang, Bin-Gui] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao 266071, Peoples R China; [Gao, Shu-Shan; Williams, Katherine] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England; [Proksch, Peter] Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany; [Ji, Nai-Yun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China
作者部门	海岸带生物学与生物资源利用所重点实验室
英文摘要	Genome mining of the fungus Mucor irregularis (formerly known as Rhizomucor variabilis) revealed the presence of various gene clusters for secondary metabolite biosynthesis, including several terpene-based clusters. Investigation into the chemical diversity of M. irregularis QEN-189, an endophytic fungus isolated from the fresh inner tissue of the marine mangrove plant Rhizophora stylosa, resulted in the discovery of 20 structurally diverse indole-diterpenes including six new compounds, namely, rhizovarins A-F (1-6). Among them, compounds 1-3 represent the most complex members of the reported indole-diterpenes. The presence of an unusual acetal linked to a hemiketal (1) or a ketal (2 and 3) in an unprecedented 4,6,6,8,5,6,6,6,6-fused indole-diterpene ring system makes them chemically unique. Their structures and absolute configurations were elucidated by spectroscopic analysis, modified Mosher's method, and chemical calculations. Each of the isolated compounds was evaluated for antitumor activity against HL-60 and A-549 cell lines.
文章类型	Article
资助机构	National Natural Science Foundation of China (NSFC)(31570356) ; NSFC-Shandong Joint Fund for Marine Science Research Centers(U1406402) ; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology(2015ASKJ02) ; Taishan Scholar Project from Shandong Province
收录类别	SCI
语种	英语
关键词[WOS]	TREMORGENIC MYCO-TOXINS ; PENICILLIUM-CRUSTOSUM THOM ; STRUCTURE ELUCIDATION ; ABSOLUTE-CONFIGURATION ; ASPERGILLUS-SULPHUREUS ; EMERICELLA-STRIATA ; PENITREM-A ; ALKALOIDS ; PAXILLINE ; INDOLODITERPENES
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
WOS记录号	WOS:000382274700019
引用统计	被引频次：70[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/17130
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao 266071, Peoples R China.; Proksch, P (reprint author), Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany.; Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China. Email:[email protected]; [email protected]; [email protected]
推荐引用方式 GB/T 7714	Gao, SS,Li, XM,Williams, K,et al. Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(8):2066-2074.
APA	Gao, SS.,Li, XM.,Williams, K.,Proksch, P.,Ji, NY.,[email protected].(2016).Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189.JOURNAL OF NATURAL PRODUCTS,79(8),2066-2074.
MLA	Gao, SS,et al."Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189".JOURNAL OF NATURAL PRODUCTS 79.8(2016):2066-2074.

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