Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property

doi:10.1021/acsami.6b01523

	Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property
	Su, XM ; Wang, YQ; Wang, WH; Sun, KX ; Chen, LX; Sun, KX (reprint author), Yantai Univ, Shandong Univ,Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Yantai 264005, Peoples R China.; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. [email protected]; [email protected]; [email protected]
发表期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
	2016-04-27
卷号	8 期号:16 页码:10201-10211
关键词	Surface-enhanced Raman Scattering (Sers) Gold Nanoparticle Lipid Bilayer Signal Stability Cell Imaging
DOI	10.1021/acsami.6b01523
产权排序	[Su, Xueming; Sun, Kaoxiang] Yantai Univ, Shandong Univ,Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Yantai 264005, Peoples R China; [Su, Xueming; Wang, Yunqing; Wang, Wenhai; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
作者部门	中科院海岸带环境过程与生态修复重点实验室
英文摘要	Surface-enhanced Raman scattering (SERS) tags draw much attention due to the ultrasensitivity and multiplex labeling capability. Recently, a new kind of SERS tags was rationally designed by encapsulating metal nano particles with phospholipid bilayers, showing great potential in theranostics. The lipid bilayer coating confers biocompatibility and versatility to changing surface chemistry of the tag; however, its "soft" feature may influence SERS signal stability, which is rarely investigated. Herein, we prepared phospholipid-coated AuNR@Ag/Au nanosphere SERS tags by using three different kinds of Raman reporters, i.e., thio-containing 4-nitrothiophenol (NT), nitrogen-containing hydrophobic chromophore cyanine 7 monoacid (Cy7), and alkyl chain-chromophore conjugate 1,1'-dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine (DiD). It was found that signal responses were different upon additional stimulation which the tags may encounter in theranostic applications including the presence of detergent Triton X-100; lipid membrane, and photothermal treatment. Living-cell imaging also showed signal changing distinction. The different SERS signal performances were attributed to the different Raman reporter releasing behaviors from the tags. This work revealed that Raman reporter structure determined signal stability of lipid-coated SERS tags, providing guidance for the design of stimulus responsive tags. Moreover, it also implied the potential of SERS technique for real time drug release study of lipid based nanomedicine.
文章类型	Article
资助机构	National Natural Science Foundation of China(81573393 ; 12th Five Years Key Programs for Science and Technology Development of China(2013ZX09402201) ; Natural Science Foundation of Shandong(ZR2014HM062 ; Science and Technology Development Plan of Shandong Province of China(2014GGF01074) ; 21305157 ; ZR2013HQ009) ; 81102415 ; 21575159)
收录类别	SCI
语种	英语
关键词[WOS]	ENHANCED RAMAN-SCATTERING ; DRUG-DELIVERY ; GOLD NANORODS ; BIOMEDICAL APPLICATIONS ; PLASMONIC NANORATTLES ; COLLOIDAL PARTICLES ; SHELL NANOPARTICLES ; LIPID-BILAYERS ; CANCER-THERAPY ; GROWTH METHOD
研究领域[WOS]	Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:000375245100017
引用统计	被引频次：36[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/17047
专题	中国科学院海岸带环境过程与生态修复重点实验室
通讯作者	Wang, YQ; Sun, KX (reprint author), Yantai Univ, Shandong Univ,Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Yantai 264005, Peoples R China.; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. [email protected]; [email protected]; [email protected]
作者单位	1.Yantai Univ, Shandong Univ,Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat
推荐引用方式 GB/T 7714	Su, XM,Wang, YQ,Wang, WH,et al. Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(16):10201-10211.
APA	Su, XM.,Wang, YQ.,Wang, WH.,Sun, KX.,Chen, LX.,[email protected].(2016).Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property.ACS APPLIED MATERIALS & INTERFACES,8(16),10201-10211.
MLA	Su, XM,et al."Phospholipid Encapsulated AuNR@Ag/Au Nanosphere SERS Tags with Environmental Stimulus Responsive Signal Property".ACS APPLIED MATERIALS & INTERFACES 8.16(2016):10201-10211.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Phospholipid Encapsu（6427KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载